Acetylation status using hydralazine in African hypertensives at Kenyatta National Hospital.
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Date
1992Author
Rashid, JR
Tsepko, Kofi
Juma, FD
Type
ArticleLanguage
enMetadata
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In this study, the investigation of hydralazine acetylator phenotype was undertaken for the first time in African hypertensives at Kenyatta National Hospital. A total of 25 randomly selected patients with moderate to severe hypertension (diastolic pressure 105-130 mmHg), participated in the phenotyping study. The phenotyping was done by administering oral standard hydralazine dose of 150 mg/day in three divided doses. The 24 hour urinary MTP/hydralazine ratio was used to categorize patients into slow and fast acetylators. Of the patients studied 69.9% were slow acetylators while 30.4% were fast acetylators. The mean 24 hour urinary MTP/hydralazine ratio for slow acetylators was 1.01 +/- 0.95. This was significantly different from the fast acetylators where the mean 24 hour urinary MTP/hydralazine ratio was 10.6 +/- 4.4 (P < 0.001). The acetylator phenotyping divided the patients into two distinct populations and no further arbitrary method was required to divide the patients into either group
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http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/1396201http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17388
Citation
East Afr Med J. 1992 Jul;69(7):406-8Collections
- Faculty of Health Sciences (FHS) [10377]