| dc.contributor.author | Juma, FD | |
| dc.contributor.author | Ogeto, John O. | |
| dc.date.accessioned | 2013-04-29T05:56:17Z | |
| dc.date.available | 2013-04-29T05:56:17Z | |
| dc.date.issued | 1989 | |
| dc.identifier.citation | Eur J Drug Metab Pharmacokinet. 1989 Jan-Mar;14(1):15-7. | en |
| dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/2668007 | |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17399 | |
| dc.description.abstract | Mefloquine pharmacokinetics were studied in Kenyan African normal volunteers and in patients with severe acute attack of Plasmodium falciparum malaria. Peak concentrations were achieved in both groups at 20-24 hours. The mean half-life of elimination was 385 +/- 150 hours (mean +/- SD) in normal subjects while in severe malaria it was 493 +/- 215 hours which was significantly longer (P less than or equal to 0.001). The volume of distribution was significantly smaller in severe malaria where it was 30.76 +/- 10.50 l/kg (mean +/- SD) while in the normal subjects it was 40.90 +/- 20.70 l/kg (mean +/- SD) (P less than or equal to 0.001). The total body clearance in severe malaria was 3.75 +/- 1.51 l/h (mean +/- SD). This was significantly lower than in the normal subjects where it was 5.15 +/- 1.50 l/h (mean +/- SD) (P less than or equal to 0.001). | en |
| dc.language.iso | en | en |
| dc.title | Mefloquine disposition in normals and in patients with severe Plasmodium falciparum malaria | en |
| dc.type | Article | en |
| local.publisher | Department of Clinical Pharmacology, University of Nairobi, Kenya. | en |
