First pass hepatic metabolism of cyclophosphamide [proceedings].
Date
1979Author
Juma, FD
Rogers, H.J
Trounce, J.R
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Cyclophosphamide itself has no alkylating activity and does not posses cytostatic effect in vitro. In vivo it undergoes activation initially by hepatic micr-somal mixed function oxidase to a number of alkylating metabolites which may be detected by their non-specific reaction
URI
http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/444373http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17452
Citation
Br J Clin Pharmacol. 1979 Apr;7(4):422P.Collections
- Faculty of Health Sciences (FHS) [10377]