Subtype C Is associated with increased vaginal shedding of HIV-1.
Date
2005-08-01Author
John-Stewart, GC
Nduati, RW
Rousseau, CM
Mbori-Ngacha, DA
Richardson, BA
Rainwater, S
Panteleeff, DD
Overbaugh, J
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The prevalence of human immunodeficiency virus (HIV)-1-infected cells and HIV-1 RNA levels in genital secretions and breast milk and the risk of mother-to-child transmission of HIV-1 were compared among subtypes A, C, and D in a Kenyan cohort. Pregnant women infected with subtype C were significantly more likely to shed HIV-1-infected vaginal cells than were those infected with subtype A or D (odds ratio [OR], 3.6 [95% confidence interval {CI}, 1.4-8.8]; P = .006). This relationship held after adjusting for age, CD4 cell count, and plasma HIV-1 RNA load (OR, 3.1 [95% CI, 1.1-8.6]; P = .03). These observations suggest that HIV-1 subtype influences mucosal shedding of HIV-1.
URI
http://www.ncbi.nlm.nih.gov/pubmed/15995964http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17529
Citation
Journal of Infectious Diseases. 2005;192(3):492-6Publisher
Department of paediatrics, University of Nairobi
Description
Journal article
Collections
- Faculty of Health Sciences (FHS) [10387]