dc.contributor.author | Rousseau, CM | |
dc.contributor.author | Nduati, RW | |
dc.contributor.author | Richardson, BA | |
dc.contributor.author | Steele, MS | |
dc.contributor.author | John-Stewart, GC | |
dc.contributor.author | Mbori-Ngacha, DA | |
dc.contributor.author | Kreiss, JK | |
dc.contributor.author | Overbaugh, J | |
dc.date.accessioned | 2013-04-29T09:24:03Z | |
dc.date.available | 2013-04-29T09:24:03Z | |
dc.date.issued | 2003-03 | |
dc.identifier.citation | Journal of Infectious Diseases. 2003;187(5):741-7 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/12599047 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17570 | |
dc.description | Journal article | en |
dc.description.abstract | Transmission of human immunodeficiency virus type 1 (HIV-1) via breast-feeding can occur throughout lactation. Defining both fluctuation in breast-milk virus level over time and how breast-milk virus correlates with mother-to-child transmission is important for establishing effective interventions. We quantified breast-milk HIV-1 RNA levels in serial samples collected from 275 women for up to 2 years after delivery. Higher maternal plasma virus load, lower maternal CD4 T cell count, and detection of HIV-1 DNA in maternal genital secretions were significantly associated with elevated breast-milk HIV-1 RNA. Within women who breast-fed, median virus load in colostrum/early milk was significantly higher than that in mature breast milk collected 14 days after delivery (P< or =.004). Breast-feeding mothers who transmitted HIV-1 to their infants had both significantly higher breast-milk viral RNA throughout lactation and more-consistent viral shedding, compared with mothers who did not transmit HIV-1. In breast-feeding women, a 2-fold-increased risk of transmission was associated with every 10-fold increase in breast-milk virus load (95% confidence interval, 1.3-3.0; P<.001). These results indicate that the risk of infant infection from breast-feeding is influenced by breast-milk virus load, which is highest early after delivery. | en |
dc.language.iso | en | en |
dc.subject | Longitudinal analysis | en |
dc.subject | Human immunodeficiency | en |
dc.subject | Virus type 1 RNA | en |
dc.subject | Breast Milk | en |
dc.subject | Infant infection | en |
dc.subject | Maternal Diseases | en |
dc.title | Longitudinal analysis of human immunodeficiency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal disease | en |
dc.type | Article | en |
local.publisher | Department of paediatrics, University of Nairobi | en |