The impact of dexamethasone on hearing loss in experimental pneumococcal meningitis.

dc.contributor.author	Bhatt, SM
dc.contributor.author	Cabellos, C,
dc.contributor.author	Nadol, JB Jr,
dc.contributor.author	Halpin, C
dc.contributor.author	Lauretano, A
dc.contributor.author	Xu, WZ
dc.contributor.author	Tuomanen, E
dc.date.accessioned	2013-04-29T10:36:35Z
dc.date.available	2013-04-29T10:36:35Z
dc.date.issued	1995
dc.identifier.citation	Pediatr Infect Dis J. 1995 Feb;14(2):93-6	en
dc.identifier.uri	http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17633
dc.description.abstract	Bacterial meningitis, particularly that resulting from Streptococcus pneumoniae, is a common cause of acquired profound sensorineural deafness in children. The pathogenesis of meningogenic hearing loss has been investigated in an experimental rabbit model. In this study significant deafness was documented within the first 15 hours of infection. Initiation of antibiotic therapy at this time diminished the severity of hearing loss in most animals. The addition of dexamethasone to antibiotic therapy prevented the development of profound deafness. These results suggest this model will be useful in developing antiinflammatory strategies to improve the outcome of bacterial meningitis.	en
dc.language.iso	en	en
dc.title	The impact of dexamethasone on hearing loss in experimental pneumococcal meningitis.	en
dc.type	Article	en