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    Effect of breastfeeding on mortality among HIV-1 infected women: a randomised trial.

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    Date
    2001
    Author
    Nduati, RW
    Richardson, BA
    John, G
    Mbori-Ngacha, DA
    Mwatha, A
    Ndinya-Achola, JO
    Bwayo, JJ
    Onyango, FE
    Kreiss, J
    Type
    Article
    Language
    en
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    Abstract
    We have completed a randomised clinical trial of breastfeeding and formula feeding to identify the frequency of breastmilk transmission of HIV-1 to infants. However, we also analysed data from this trial to examine the effect of breastfeeding on maternal death rates during 2 years after delivery. We report our findings from this secondary analysis. METHODS: Pregnant women attending four Nairobi city council clinics were offered HIVtests. At about 32 weeks' gestation, 425 HIV-1 seropositive women were randomly allocated to either breastfeed or formula feed their infants. After delivery, mother-infant pairs were followed up monthly during the first year and quarterly during the second year until death, or 2 years after delivery, or end of study. FINDINGS: Mortality among mothers was higher in the breastfeeding group than in the formula group (18 vs 6 deaths, log rank test, p=0.009). The cumulative probability of maternal death at 24 months after delivery was 10.5% in the breastfeeding group and 3.8% in the formula group (p=0.02). The relative risk of death for breastfeeding mothers versus formula feeding mothers was 3.2 (95% CI 1.3-8.1, p=0.01). The attributable risk of maternal death due to breastfeeding was 69%. There was an association between maternal death and subsequent infant death, even after infant HIV-1 infection status was controlled for (relative risk 7.9, 95% CI 3.3-18.6, p<0.001). INTERPRETATION: Our findings suggest that breastfeeding by HIV-1 infected women might result in adverse outcomes for both mother and infant.
    URI
    http://www.ncbi.nlm.nih.gov/pubmed/11425369
    http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17672
    Citation
    Lancet. 2001 May 26;357(9269):1651-5.
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