Genital shedding of human immunodeficiency virus type 1 DNA during pregnancy: association with immunosuppression, abnormal cervical or vaginal discharge, and severe vitamin A deficiency
View/ Open
Date
1997-01Author
John, G
Nduati, RW
Mbori-Ngacha, DA
Overbaugh, J
Welch, M
Richardson, B
Ndinya-Achola, JO
Bwayo, JJ
Krieger, J
Onyango, F
Kreiss, J K
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The presence of human immunodeficiency virus type 1 (HIV-1) in genital secretions may be a determinant of vertical HIV-1 transmission. Cervical and vaginal secretions from HIV-1–seropositive pregnant women were evaluated to determine prevalence and correlates of HIV-1–infected cells in the genital tract. HIV-1 DNA was detected by polymerase chain reaction in 32% of 212 cervical and 10% of 215 vaginal specimens. Presence of HIV-1 DNA in the cervix was associated with cervical mucopus and a significantly lower absolute CD4 cell count (354 vs. 469, P < .001). An absolute CD4 cell count <200 was associated with a 9.6-fold increased odds of cervical HIV-1 DNA detection compared with a count ≥500 (95% confidence interval, 2.8–34.2). Detection of vaginal HIV-1 DNA was associated with abnormal vaginal discharge, lower absolute CD4 cell count, and severe vitamin A deficiency. Presence of HIV-1–infected cells in genital secretions was associated with immunosuppression and abnormal cervical or vaginal discharge.
URI
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372419/http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17687
Citation
Journal of Infectious Diseases.1997;175(1):57-62Publisher
Department of paediatrics, University of Nairobi
Subject
Genital SheddingHuman Immunodeficiency Virus Type 1 DNA
Pregnancy
Immunosuppression
Abnormal Cervical or Vaginal Discharge
Severe Vitamin A Deficiency
Description
Journal article
Collections
- Faculty of Health Sciences (FHS) [10387]