• Login
    • Login
    Advanced Search
    View Item 
    •   UoN Digital Repository Home
    • Journal Articles
    • Faculty of Health Sciences (FHS)
    • View Item
    •   UoN Digital Repository Home
    • Journal Articles
    • Faculty of Health Sciences (FHS)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Heterogeneity in host HIV susceptibility as a potential contributor to recent HIV prevalence declines in Africa

    Thumbnail
    View/Open
    Abstract.pdf (184.2Kb)
    Date
    2009
    Author
    Nagelkerke, Nico J D
    Vlas, Sake J de
    Jha, Prabhat
    Luo, Ma
    Plummer, Francis A
    Kaul, Rupert
    Type
    Article
    Language
    en
    Metadata
    Show full item record

    Abstract
    Background HIV prevalence has recently declined in several African countries, and prior to this the risk of HIV acquisition per unprotected sex contact also declined in Kenyan sex workers. We hypothesized that heterogeneity in HIV host susceptibility might underpin both of these observations. Methods A compartmental mathematical model was used to explore the potential impact of heterogeneity in susceptibility to HIV infection on epidemic behavior, in the absence of other causative mechanisms. Results Studies indicated that a substantial heterogeneity in susceptibility to HIV infection,, may lead to an epidemic that peaks and then declines due to a depletion of the most susceptible individuals, even without changes in sexual behavior. This effect was most notable in high-risk groups such as female sex workers, and was consistent with empirical data. Discussion Declines in HIV prevalence may have other causes in addition to behavior change, including heterogeneity in host HIV susceptibility. There is a need to further study this heterogeneity and its correlates, particularly as it confounds the ability to attribute HIV epidemic shifts to specific interventions, including behavior change.
    URI
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764323/
    http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/19699
    Citation
    AIDS. 2009 January 2; 23(1): 125–130.
    Publisher
    Department of Medical Microbiology
    Subject
    HIV-1 transmission
    Epidemiology
    Modeling
    Description
    Full text
    Collections
    • Faculty of Health Sciences (FHS) [10214]

    Copyright © 2022 
    University of Nairobi Library
    Contact Us | Send Feedback

     

     

    Useful Links
    UON HomeLibrary HomeKLISC

    Browse

    All of UoN Digital RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Copyright © 2022 
    University of Nairobi Library
    Contact Us | Send Feedback