The Breadth and Potency of Passively Acquired Human Immunodeficiency Virus Type 1-Specific Neutralizing Antibodies Do Not Correlate with the Risk of Infant Infection[down-pointing small open triangle]
Date
2011Author
Lynch, John B
Nduati, RW
Blish, Catherine A
Richardson, Barbra A
Mabuka, Jennifer M
Jalalian-Lechak, Zahra
John-Stewart, Grace
Overbaugh, Julie
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Although a major goal of human immunodeficiency virus type 1 (HIV-1) vaccine efforts is to elicit broad and
potent neutralizing antibodies (NAbs), there are no data that directly demonstrate a role for such NAbs in
protection from HIV-1 infection in exposed humans. The setting of mother-to-child transmission provides an
opportunity to examine whether NAbs provide protection from HIV-1 infection because infants acquire passive
antibodies from their mothers prior to exposure to HIV-1 through breastfeeding. We evaluated the charac-
teristics of HIV-1-specific NAbs in 100 breast-fed infants of HIV-1-positive mothers who were HIV-1 negative
at birth and monitored them until age 2. A panel of eight viruses that included variants representative of those
in the study region as well as more diverse strains was used to determine the breadth of the infant NAbs. From
their mothers, infants acquired broad and potent NAbs that were capable of recognizing heterologous circu-
lating HIV-1 variants of diverse subtypes, but the presence of NAbs of broad HIV-1 specificity was not
associated with transmission risk. There was also no correlation between responses to any particular virus
tested, which included a range of diverse variants that demonstrated different neutralization profiles, including
recognition by specific antibodies with known epitope targets. The eight viruses tested exhibited neutralization
profiles to a variety of monoclonal antibodies (2F5, PG9, and VRC01) similar to those of viruses present in
pregnant women in the cohort. These results suggest that the breadth and potency of the heterologous antibody
response in exposed infants, measured against a virus panel comprised of variants typical of those circulating
in the population, does not predict protection
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/19964http://www.ncbi.nlm.nih.gov/pubmed/21411521
Citation
J Virol. 2011 June; 85(11): 5252–5261.Publisher
Department of Pediatrics
Description
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Collections
- Faculty of Health Sciences (FHS) [10387]