A comparative study to screen dementia and APOE genotypes in an ageing East African population
Date
2010Author
Chen, Chien-Hsiun
Mizuno, Toshiki
Elston, Robert
Kariuki, Monica M
Hall, Kathleen
Unverzagt, Fred
Hendrie, Hugh
Gatere, Samuel
Kioy, Paul
Patel, Nilesh B
Friedland, Robert P
Kalaria, Raj N
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Previous studies have established cross-cultural methods to screen for ageing- related dementia and susceptibility genes, in particular Alzheimer’s disease (AD) among the Canadian Cree, African Americans and Yoruba in Nigeria. We determined whether the Community Screening Interview for Dementia (CSID), translated into Kikuyu, a major language of Kenya, could be used to evaluate dementia of the Alzheimer type. Using two sets of coefficients of cognitive and informant scores, two discriminant function (DF) scores were calculated for each of 100 elderly (>65 years) Nyeri Kenyans. When the cut-off points were selected for 100% sensitivities, the specificities of the DF scores were remarkably similar (93.75%) in the Kenyan sample. We propose the adapted CSID can be utilised to detect dementia among East Africans. We also show that apolipoprotein E ε4 allele frequencies were high (∼30%) and not different between normal subjects and those with probable AD. There was no evidence to suggest years of education or vascular factors were associated with dementia status.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/21618http://www.ncbi.nlm.nih.gov/pubmed/18703255
Citation
Neurobiol Aging. 2010 May; 31(5): 732–740.Publisher
Department of Medical Physiology
Description
Full text
Collections
- Faculty of Health Sciences (FHS) [10377]