dc.contributor.author | Farquhar, Carey | |
dc.contributor.author | Lohman-Payne, Barbara | |
dc.contributor.author | Overbaugh, Julie | |
dc.contributor.author | Richardson, Barbra A | |
dc.contributor.author | Mabuka, Jennifer | |
dc.contributor.author | Bosire, Rose | |
dc.contributor.author | Mbori-Ngacha, DA | |
dc.contributor.author | John-Stewart, Grace | |
dc.date.accessioned | 2013-05-12T11:29:44Z | |
dc.date.available | 2013-05-12T11:29:44Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | J Infect Dis. 2011 December 1; 204(11): 1806–1810. | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/22478 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/21984736 | |
dc.description | Full text | en |
dc.description.abstract | Background. Although evidence supports a relationship between human immunodeficiency virus (HIV)–1 exposure and HIV-1−specific CD8+ T cell responses, studies have not demonstrated a direct association between the quantity of HIV-1 to which a person is exposed and the presence or absence of a response.
Methods. From 1999 to 2005, maternal HIV-1 RNA levels were measured in blood, cervical secretions, and breast milk at delivery and 1 month after delivery. HIV-1−specific interferon (IFN)–γ Elispot assays were conducted to determine infant CD8+ T-cell responses at 3 months of age.
Results. Among 161 infants tested with Elispot assays, 23 (14%) had positive results. Mothers whose infants had a positive assay had higher breast milk HIV-1 RNA levels at month 1 compared with mothers whose infants had negative Elispot assays (3.1 vs 2.5 log10 copies/mL; P = .017). Female infants were also more likely to have positive Elispot assays than male infants (P = .046), and in multivariate analyses, both female sex and high breast milk HIV-1 levels remained important predictors of a positive response (P = .022 and P = .015, respectively).
Conclusions. Exposure to breast milk HIV-1 and sex were associated with development of HIV-1−specific CD8+ T-cell responses in infants. These data support a role for mucosal exposure via the oral route in induction of systemic HIV-1−specific cellular immunity. | en |
dc.language.iso | en | en |
dc.subject | Breast Milk | en |
dc.subject | Female Sex | en |
dc.subject | HIV-1 | en |
dc.subject | Infants | en |
dc.subject | CD8+ | en |
dc.title | Breast Milk HIV-1 RNA Levels and Female Sex Are Associated With HIV-1–Specific CD8+ T-Cell Responses in HIV-1–Exposed, Uninfected Infants in Kenya | en |
dc.type | Article | en |
local.publisher | Department of Paediatrics | en |