dc.contributor.author | Atul, JP | |
dc.date.accessioned | 2013-05-23T14:07:17Z | |
dc.date.available | 2013-05-23T14:07:17Z | |
dc.date.issued | 1984 | |
dc.identifier.citation | Masters of Medicine (Paediatrics) | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/11295/24998 | |
dc.description.abstract | During a 9 month period, 106 consecutive episodes of fever
in 50 children with haematological malignancies were prospectively
evaluated. The distribution of the haematologic malignancies
were as follows: 17 cases had acute lymphocytic
leukaemia; 18 malignant lymphoma (8 Hodgkin1s , 8 Burkitt1s
and 2 lymphocytic lymphoma); 3 chronic granulocytic leukaemia
and 12 acute non-lymphocytic leukaemia.
The common clinical diagnoses associated with febrile episode
and positive isolates included septicemia (17 cases) pneumonia
(11 cases), oral infections (11 cases) suppurative cutaneous
lesions (7 cases) pharyngitis (9 cases) perianal infections
(4 cases) and typhoid (3 cases).
62.3% of the episodes were aetiologically documented by
bacterial isolates. Crystaline pencillin, Gentamicin and
Co-trimoxazole were the most commonly employed antibiotics. Of
the 80 bacterial isolates the most common were Staphylococcus
aureus (28.8%) Klebsiella (20%), Streptococcus faecal is (15%)
Staphylococcus albus (12.5%) and Escherichia coli (11.3%)
There was one case of systemic candidiasis. Other isolates
unrelated to fever were tinea (5 cases) and incidental findings
of Hookworm and Trichuris trichuria in two specimens of stool.
Viral infections diagnosed clinically included 4 cases of
varicella, 2 of measles, 1 herpes labialis and 2 hepatitis.
The mortality in this series was 52% (80% of those admitted
in relapse had a fatal outcome). 61.5% of the deaths were due
to infections.
It may therefore be concluded from this study that in children
with haematological malignancies (1) infection is a frequent
cause of mortality (2) the most common cause of febrile
episodes is bacterial infection (3) Staphylococcus aureus,
Klebsiella, Escherichia coli and Streptococcus faecalis
are the most frequent bacterial isolates and Pseudomonas
is infrequent. (4) viral infections are relatively
frequent in this group of children and (5) with adequate
management the mortality can be reduced. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | The pattern of infections in children with haematological malignancies undergoing treatment at Kenyatta National Hospital. | en |
dc.type | Thesis | en |
dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |
local.publisher | School of Medicine | en |