The value of single dose flucloxacillin in clean major surgical operations
Abstract
A Randomized Prospective study to review the value of single dose
Flucloxacillin as antibiotic prophylaxis in clean major surgical operations
(Thyroidectomy, herniorrhaphy and mastectomy) was carried out at Kenyatta
National Hospital, general surgical unit.
Patients were recruited according to Inclusion/Exclusion criteria and
randomized into two groups. One to receive the antibiotic and the other group
not receiving antibiotic prophylaxis.
The study used flucloxacillin as antibiotic prophylaxis with randomization of
patients receiving the antibiotic at induction of anaesthesia, as a single bolus
dose intravenously.
The surgical outcome was gauged by the rate of surgical wound infection in
the wards and within 14 days post operatively.
The data was analysed after compilation of the questionnaires.
The age range was 17 years to 62 years with a mean age of32 years.
380 patients were recruited to the study;
Female to Male ratio was 2:1 with 256 females and 124 males.
133 (350/0) patients underwent mastectomy, 125 (33%) Thyroidectomy and
122 (32%) Herniorrhaphy.
188 received antibiotic prophylaxis and 1 (0.5%) out of this group developed
wound infection.
192 patients did not receive prophylaxis and 3 (1.6%) out of this group
developed wound infection.
Thus fewer patients developed wound infection with antibiotic prophylaxis
compared to those who did not receive any prophylaxis.
These data can be used as a baseline to develop guidelines and standing orders
for surgical prophylactic regimens
Citation
Master of Medicine in Surgery, University of Nairobi, 2002Publisher
University of Nairobi. Faculty of Medicine