Thrombocytopenia in haart naive HIV infected Patients attending the comprehensive care Clinic at Kenyatta national hospital
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Date
2010Author
Ong'ondi, Matilda K
Type
ThesisLanguage
enMetadata
Show full item recordAbstract
Background:
Haematological abnormalities are common in HIV infected patients. Thrombocytopenia has been
associated with progression of disease. The presence of thrombocytopenia is significantly
associated with decreased survival and is a predictor of mortality.
Objective:
To study the prevalence of thrombocytopenia and clinical characteristics in HIV infected patients
who are HAART naive attending the Kenyatta National Hospital Comprehensive Care Centre.
Study Design
A cross sectional Descriptive Study.
Study site:
Kenyatta National Hospital Comprehensive Care Centre
Methods:
HIV positive HAART narve patients who fulfilled the study inclusion criteria were recruited.
History and physical examination was done. Blood was drawn for total blood count, Peripheral
blood film and CD4 count.
RESULTS
340 HIV infected HAART naive patients with a mean age of 37.3years and range of 18years to
72years were recruited. The male to female ratio was 1:1.6.The study population mostly
comprised of; young patients (39.9% between 30-40yrs), females (61.6%) in WHO clinical stage
I (57.6%) and with CD4 count between 200-500 cell/mm3
. The mean platelet count was 230,000
cells/ul. The prevalence of thrombocytopenia in this population was 3.8%.
Most of the patients with thrombocytopenia had a bicytopenia with the rest having isolated
thrombocytopenia or pancytopenia. Bleeding tendencies were more in the thrombocytopenia
group (p= 0.011). Patients in WHO Clinical Stage IV were more likely to have
thrombocytopenia (p <0.011) as well as those with CD4 count < 200cells/mm3 (p <0.050).
Conclusion
The prevalence of thrombocytopenia is low among HIV infected HAAR T naive patients
attending the Kenyatta National Hospital Comprehensive Care Clinic. This could be attributed to
young age, predominant female gender and early disease in the study population.
Citation
Master of Medicine (internal medicine)Publisher
University Of Nairobi College of Health Sciences