Posterior capsular opacification at Lions Sight First Eye Hospital
Abstract
Objective: To determine the factors associated with posterior capsular opacification (PC0) at
Lions Sight First Eye Hospital (LSFEH).
Design: Case control study
Setting: Lions Sight First Eye Hospital
Subjects: 130 patients who underwent cataract surgery in LSFEH meeting the inclusion criteria:
65 cases and 65 controls. The cases were the patients who had posterior capsular opacification,
diagnosed using a slit lamp, and who required capsulotomy. The controls were patients who did
not develop posterior capsular opacification two years post cataract surgery.
Data collection: Data was collected using questionnaires and analysed using SPSS version 11.5.
Results: The ratio of males: female was 1:1.32. The mean age of the cases was 57.4 years as
compared to the controls of 64.0 years, which was statistically significant(p<0.017). AcrySof ®
lens had PCO rate of 20(33.3%), which was lower than Poly methyl methacrylate (PMMA) lens
of 45(64.3%) (p<0.001). All the 10 patients with prior uveitis developed PCO. Diabetics were
noted to have significantly less PCO rates compared to the non-diabetic patients (p=0.028).
There was no significant difference between the phaco-emulsification and manual small incision
cataract surgery (MSICS) method of surgery. After multivariate analysis pea was found to be
associated with type of IOL [adjusted (adj) OR 0.28,95% CI 0.13, 0.61] and Diabetes Mellitus
(adj OR 0.33, 95% CI 0.13-0.88).
Conclusion: AcrySof ® lens has lower PCO rates compared to PMMA. The method of surgery
(MSICS vis Phaco-emulsification) had no impact on pea rates. Diabetic patients had less PCO
rates in comparison to the non- diabetics. The factors which may predict risk of PCO are the type
of lens and diabetes.
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Recommendation: AcrySof ® lens be the preferred intra-ocular lens (IOL) to reduce posterior
capsular opacification rates post cataract surgery when affordable.
Citation
Master of Medicine, OphthalmologyPublisher
University of Nairobi College of Health Sciences