| dc.contributor.author | Rashid, JR | |
| dc.date.accessioned | 2013-05-24T08:43:10Z | |
| dc.date.available | 2013-05-24T08:43:10Z | |
| dc.date.issued | 1988 | |
| dc.identifier.citation | Master Of Medicine (Medicine) | en |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/11295/25254 | |
| dc.description.abstract | In the present study investigation of hydrallazine acetylator phenotype was undertaken for the first time in hypertensive Africans. A total of 25 randomly selected patients with moderate to
severe hypertension participated in the phenoty- ping study. The phenotyping was done by administration of oral standard hydrallazine dose
of l50mg/day. The 24 hour urinary MTP/hydrallazine
ratio was used to categ..orise patients into slow and fast acetylators.
Of the patients studied 69.9% were slow acetylators while 30.4% were fast acetylators. The mean 24 hour urinary MTP/hydrallazine ratio for slow acetylators was 1.0,1± 0.95 mean ± SD. This was significantly different from fast acetylator phenotype where the mean 24 hour urinary MTP/hydrallazine was 10.6±4.4 mean ±SD (P<O.OOl).
The acetylator phenotyping divided the patients studied into two distinct populations and no further arbitrary method was required to divide the patient into either group. | en |
| dc.language.iso | en | en |
| dc.publisher | University Of Nairobi | en |
| dc.title | A study of acetylation status using hydrallazine in African Hypertensives at Kenyatta National Hospital | en |
| dc.type | Thesis | en |
| dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |
| local.publisher | Department of Medicine | en |
