dc.contributor.author | Nyoro, Mukuha M | |
dc.date.accessioned | 2013-05-24T09:43:08Z | |
dc.date.available | 2013-05-24T09:43:08Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | Masters of Medicine | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/11295/25335 | |
dc.description.abstract | Sickle cell anemia is one of the most common genetic
disorders with more than 200 million carriers of sickle cell traits worldwide.
With increasing survival into adulthood there has been an increase in chronic
organ failure and the lung is among the major organs involved contributing
to significant mortality and morbidity .
To determine the prevalence and severity of pulmonary
dysfunction in patients with sickle cell anemia in steady state at K.N.H.
A cross sectional comparative study.
Confirmed SCA patients on HB electrophoresis who were
12 years and above and the controls were life long non smokers matched for
age and sex.
A total of 160 cases comprising 80 SCA patients and an
equal number of controls were recruited.
History was taken and physical examination done. Spirometry was
done and their TLC,RV, FEV1, FVC, FEV1IFVC ratio and resting pulse
oximetry were taken
Eighty (80) sickle cell anemia patients in stable state and eighty (80)
healthy controls were studied. The meal) age of the SCA patients was 17.35
+/- 3.49 with a range of 12-42 years. The majority comprising 58.8% were
in the age group of 12 up t019 years with only 6.2 % being above 30 years
of age. The male to female ratio was 1:1.
SCA patients had significantly reduced TLC, RV, FEV1 %, FVC% with an
increased FEV1 to FVC ratio in keeping with a restrictive defect. The
restrictive defect also showed significant negative relationship with number
of crises and number of transfusions.
SCA patients have predominantly a restrictive pattern of
pulmonary dysfunction. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Assessment Of ,pulmonary Functions In Patients With Sickle Cell Anemia In Steady State At Kenyatta National Hospital | en |
dc.type | Thesis | en |
dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |
local.publisher | School of Medicine | en |