dc.contributor.author | Mwangi, Jane | |
dc.date.accessioned | 2013-05-25T07:12:03Z | |
dc.date.available | 2013-05-25T07:12:03Z | |
dc.date.issued | 1989 | |
dc.identifier.citation | Masters of Medicine (Pathology) | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/11295/25561 | |
dc.description.abstract | played by Hepatitis B Virus in the causation of hepatocellular
carcinoma and liver cirrhosis in Kenya.
Liver biopsy samples were stained by the orcein
histochemical method and peroxidase-anti-peroxidase
immunohistochemical method to check for the presence of
Hepatitis B surface antigen and Hepatitis B core antigen.
The study included 108 cases of hepatocellular carcinoma,
35 cases of liver cirrhos~s and 40 normal liver biopsies.
Analysis of the results revealed the following important
facts:
1) Only 2.5% of normal livers had HBSAg.
2) In contrast 33% of hepatocellular carcinoma and
26% of liver cirrhosis cases had HBSAg.
3) Background cirrhosis was found in 52% of HCC cases.
4) Positivity of HBSAg 1S more demonstrable in open
liver biopsies than in needle biopsies;about 44%
positivity as opposed to 10% in cirrhosis respectively.
5) Cases of liver cirrhosis show a higher positivity
for HBCAg than HCC cases; 14% and 11.5% respectively.
More cases of cirrhosis were positive for both HBSAg
and HBCAg than HCC
6) This study also ?ocuments that viral antigens are
randomly distributed in non-neoplastic tissue
and therefore its demonstration is proportional to
the amount of tissue examined.
7) Survival of the antigen in tissue depends on the
type and concentration of fixative, fixation time
and size of specimen. The antigen is destroyed or
altered at temperatures above 60 C.
8) The orcein histocehmical stain is as sensitive as'
the Peroxidase-anti-Peroxidase immunohistochemical
stain in the detection of HBSAg.
Current views on the aetiology of hepatocellular
carcinoma are discussed and preventive measures suggested. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Some aspects of hepatocellular carcinoma and liver cirrhosis in Kenya | en |
dc.type | Thesis | en |
dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |
local.publisher | School of Medicine | en |