dc.contributor.author | Githang'a, Jessie N | |
dc.date.accessioned | 2013-05-25T07:20:49Z | |
dc.date.available | 2013-05-25T07:20:49Z | |
dc.date.issued | 1989 | |
dc.identifier.citation | Masters of Medicine (Pathology) | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/11295/25566 | |
dc.description.abstract | This is a prospective study of 14 patients aged from
ten months to 13 years admitted to KNH with acute leukaemia
(AL). Chromosomal analysis was successfully performed in
nine children. The clinical and laboratory features of the
patients were also analysed in relation to cytogenetic
abnormalities identified.
The study revealed that eight out of 14 (57!1~) of the
patients had acute non-lymphocytic leukaemia (ANLL) and 43%
had acute lymphoblastic leukaemia (ALL). Out of the five
children with ANLL who had chromosomal analysis performed
three (60%) had karyotype abnormal it i es: two pat i en ts had
hyperdiploidy, one with AML M5a had 47 chromosomes, and the
other with AML M2 had trisomy 21; the third patient had
monosomy 7. None of the four patients with ALL who had
chromosomal analysis performed had any karyotype
abnormalities.
Four out of the nine patients, whose karyotypes were
determined, died. All the four had normal karyotypes . Two
died of haemorrhage having had platelet counts less than 20
x 109/1 which is a poor prognostic feature. The other two
died of overwhelming infections.
Surface marker studies done during the course of the
study were helpful in making a final
complemented the morphological diagnosis.
diagnosis and
Evidence from the study shows that karyotypic
abnormalities in ANLL occur as frequently as those found in
other studies. The prognostic significance of the
chromosomal abnormalities has not been clearly demonstrated
in this study in view of the sample size. It is therefore
recommended that further similar but larger studies be
performed. A larger study should also bring out any
associations between certain karyotypes and morphologi cal
types of acute leukaemia. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Chromosomal Abnormalities In Childhood Acute Leukaemia At Kenyatta National Hospital, Nairobi | en |
dc.type | Thesis | en |
dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |
local.publisher | School of Medicine | en |