dc.contributor.author | Ndwigah, Lucy | |
dc.date.accessioned | 2013-05-25T07:24:03Z | |
dc.date.available | 2013-05-25T07:24:03Z | |
dc.date.issued | 1989 | |
dc.identifier.citation | Masters of Medicine (Pathology) | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/11295/25568 | |
dc.description.abstract | This is a retrospective study of the histological patterns of
tuberculous lymphadenitis. Four histological patterns of
tuberculosis have been described. The main objective was to
review the histology of tuberculous lymphadenitis as seen at
Kenyatta National Hospital and categorise it in the generally
accepted histological spectrum of tuberculosis made-up of the
four groups that define the spectrum. The study showed that such
a spectrum forms a rational basis for the histological
classification that would relate to the immune status. The
spectrum has two polar groups, at one end morphologically
characterised by extensive necrosis and poor and disorganised
cellular response and abundant tubercle bacilli. This group of
patients are likely to have a relatively rapidly progressive and
disseminated disease. The other end of the spectrum is
characterised by a proliferative cellular lesion with
lymphocytes, macrophages and fibroblasts and minimum tissue
destruction and scanty microorganisms. The middle groups show
intermediate responses. This classification has been found to be
reproducible and its main application lies in its extrapolation
to the likely clinical course of the disease. The finding that
most of the cases lay in the intermediate groups of the spectrum
agrees with the local experience that our patients show a
relatively poor immunological response to Mycobacterium
tuberculosis the suggested compounding factors being concurrent
multiple parasitic infections and poor nutrition. Of the two
methods for demonstrating acid-fast bacilli in tissue that were
used the fluorochrome method proved the more sensitive over the
traditional time-honoured Ziehl-Neelsen method. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | The histological patterns of tuberculous lymphadenitis as seen at Kenyatta National Hospital | en |
dc.type | Thesis | en |
dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |
local.publisher | School of Medicine | en |