dc.contributor.author | Macharia, Martin W | |
dc.date.accessioned | 2013-05-25T07:52:23Z | |
dc.date.available | 2013-05-25T07:52:23Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Master of Medicine, Obstetrics & Gynaecology | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/11295/25590 | |
dc.description.abstract | Backqround
The benefit of antibiotic prophylaxis in both emergency and elective caesarean
section has been demonstrated repeatedly in studies, mostly in western
countries. Most of these studies have not demonstrated significant differences
between single and multiple dosing regimens. Single dose regimens are not
generally used in Kenyatta National hospital and other public institutions.
Objective: To compare the incidence of any puerperal infections among women
receiving a single high dose Crystalline penicillin plus Gentamicin intra-operatively
with those receiving a three day regular dose Crystalline penicillin plus
Gentamicin as prophylaxis during elective caesarean section at Kenyatta National
Hospital.
Study DesigJ!.:This was a Randomized, Double-blinded Clinical Trial
Studv Area: The study was conducted at Kenyatta National Hospital, Nairobi,
Kenya.
Study population: The study population constituted women admitted at Kenyatta
National Hospital for elective Caesarean section.
Outcome measures: These were post-partum fever, surgical site (wound)
infection and clinical endometritis.
Results: 75 questionnaires were administered but only 72 were analysed (36 for
each arm of the study). There were no significant differences in the sociodemographic
characteristics, pre-operative obstetric characteristics and
laboratory profiles. There were also no significant differences in the postoperative
clinical indicators of puerperal infection, which were fever (p=l), wound
infection, uterine tenderness (p=O.396), uterine sub-involution (p=O.164) and the
colour (p=O.543) and smell of lochia. Fever was the only recorded clinical indicator
of infection, though this did not meet the criteria specified for post-partum febrile
illness.
10
Conclusion and recommendation: A single high-dose of Crystalline penicillin and
gentamicin is as effective as multiple regular-dose Crystalline penicillin and
gentamicin as prophylaxis against puerperal infection in women undergoing
elective caesarean section. It is therefore recommended | en |
dc.language.iso | en | en |
dc.publisher | University Of Nairobi | en |
dc.title | Antibiotic prophylaxis in elective caesarean section: single dose Compared to multiple dose antibiotics: a randomized clinical trial | en |
dc.type | Thesis | en |
dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |
local.publisher | College of Health Sciences | en |