dc.contributor.author | Kamaku, Mercy W | |
dc.date.accessioned | 2013-05-25T08:14:09Z | |
dc.date.available | 2013-05-25T08:14:09Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Master Of Science In Medical Physiology At The University Of Nairobi,2009 | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/11295/25604 | |
dc.description.abstract | The use of traditional and herbal medicines has continued to grow globally. One particular
herbal medicinal product, Enzoy has continued to gain widespread popularity as a remedy for
self-medicated treatment of infertility and impotence.
The effects of Enzoy were investigated on isolated perfused rabbit heart and jejunum
whereby the organic extract was administered and found to exhibit spontaneous rhythmic
contractions. The administration of organic extract of Enzoy (OEE) at different
concentrations of 0.5, 1.0, 2.0, 4.0, 8.0 mg/ml respectively on isolated perfused rabbit heart
caused a decrease in the number and amplitude of contractions. A dose of3.2 (± 0.34) mg/ml
caused a 50% change in the number of contractions and a dose of 0.70 (± 0.51) mg/ml caused
a similar change in the amplitude of contractions (p< 0.05). High concentrations of 4.0 and
8.0 mg/ml significantly inhibited both in the number and amplitude of heart contractions (p<
0.05), while. Low concentrations 0.5 and 1.0 mg/ml of OEE caused significant decrease in
the amplitude of contractions (p< 0.05) but no significant decrease in the number of
contractions occurred.
Similarly on the isolated rabbit jejunum the different concentrations were 0.05, 0.1, 0.2, 0.4,
0.8 mg/ml, which caused a decrease in the number and amplitude of contractions with a dose
of 0.22 (± 0.04) mg/ml and 0.05 (±0.01) mg/ml being particularly potent (p< 0.05). Similarly
high concentrations (0.2, 0.4, and 0.8) mg/ml of OEE decreased significantly inhibited (p<
0.05) both in the number and amplitude of jejunum contractions. Low concentrations (0.1
and 0.05 mg/ml) of OEE caused a significant decrease in the amplitude of contractions but no
significant decrease in the number of jejunum contractions occurred.
The decrease in the number and amplitude of contractions caused by OEE on the isolated
heart and jejunum preparations respectively shows marked relaxation of cardiac and smooth
muscle cells. OEE caused a parasympathomimetic effect on the heart since it caused an
inhibitory effect on the number and amplitude of contractions. On the isolated jejunum OEE
caused a sympathomimetic effect by producing inhibitory effect on both the number and
amplitude of contractions. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Effects Of Organic Extract Of Enzoy On Isolated Rabbit Heart Andjejunum | en |
dc.type | Thesis | en |
dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |
local.publisher | Faculty of medicine | en |