Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection.
dc.contributor.author | Kimani, J | |
dc.contributor.author | Oyugi, J | |
dc.contributor.author | Njagi, Elizabeth N | |
dc.contributor.author | Wade, J | |
dc.contributor.author | Krausa, P | |
dc.contributor.author | Rowland-Jones, S | |
dc.contributor.author | Ngugi, E | |
dc.contributor.author | Bwayo, JJ | |
dc.contributor.author | Plummer, FA | |
dc.contributor.author | Luscher, M A | |
dc.contributor.author | Brunham, R C | |
dc.contributor.author | MacDonald, K S | |
dc.contributor.author | Fowke, K R | |
dc.contributor.author | Dunand, V A | |
dc.contributor.author | Nagelkerke, N J | |
dc.contributor.author | Ball, T B | |
dc.contributor.author | Gaur, L K | |
dc.date.accessioned | 2013-05-26T08:59:29Z | |
dc.date.available | 2013-05-26T08:59:29Z | |
dc.date.issued | 2000-05 | |
dc.identifier.citation | J Infect Dis. 2000 May;181(5):1581-9. Epub 2000 May 8 | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/25889 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/10823757 | |
dc.description.abstract | Certain human leukocyte antigens, by presenting conserved immunogenic epitopes for T cell recognition, may, in part, account for the observed differences in human immunodeficiency virus type 1 (HIV-1) susceptibility. To determine whether HLA polymorphism influences HIV-1 susceptibility, a longitudinal cohort of highly HIV-1-exposed female sex workers based in Nairobi, Kenya, was prospectively analyzed. Decreased HIV-1 infection risk was strongly associated with possession of a cluster of closely related HLA alleles (A2/6802 supertype; incidence rate ratio [IRR], 0.45; 95% confidence interval [CI], 0.27-0.72; P=.0003). The alleles in this supertype are known in some cases to present the same peptide epitopes for T cell recognition. In addition, resistance to HIV-1 infection was independently associated with HLA DRB1*01 (IRR, 0.22; 95% CI, 0.06-0.60; P=.0003), which suggests that anti-HIV-1 class II restricted CD4 effector mechanisms may play an important role in protecting against viral challenge. These data provide further evidence that resistance to HIV-1 infection in this cohort of sex workers is immunologically mediate | en |
dc.language.iso | en | en |
dc.publisher | en | |
dc.title | Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection. | en |
dc.type | Article | en |
local.publisher | Department of Medicine | en |
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