Association between cervical inflammation and cervical shedding of human immunodeficiency virus DNA
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Date
1994-12Author
Kreiss, J
Willerford, DM
Hensel, M
Emonyi, W
Plummer, F
Ndinya-Achola, JO
Roberts, PL
Hoskyn, J
Hillier, S
Kiviat, N
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
A cross-sectional study was conducted among prostitutes in Nairobi, Kenya, to determine the prevalence and correlates of cervical human immunodeficiency virus (HIV) DNA. Ninety-two HIV-seropositive prostitutes were evaluated during 137 clinic visits. Cervical HIV DNA was detected by polymerase chain reaction assay in 36 (39%) women at initial visits and in 40 (44%) women at any visit. There was a significant correlation between cervical HIV and microscopic evidence of cervical inflammation (odds ratio [OR], 7.2; 95% confidence interval [CI], 2.1-24.6). Using multivariate analysis to adjust for possible confounding, the adjusted OR for the association between cervical inflammation and cervical HIV DNA was 8.7 (95% CI, 2.0-37.2). Conditions associated with cervical inflammation are associated with the detection of HIV proviral DNA. Whether such conditions lead to increased infectivity remains to be proven.
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http://profiles.uonbi.ac.ke/jndinya/publications/kreiss-j-willerford-dm-hensel-m-emonyi-w-plummer-f-ndinya-achola-j-roberts-pl-hhttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/28012
Citation
J Infect Dis. 1994 Dec;170(6):1597-601., (1994)Publisher
University of Nairobi Faculty of medicine
Collections
- Faculty of Health Sciences (FHS) [10377]