|dc.contributor.author||Burszytyn, Peter George R||
|dc.description.abstract||1) Intravenous infusion of aldosterone raises the arterial
pressure 20% in five hours.
2) Inprogesterone pretreated animals, aldosterone infusion
raises the arterial pressure 45% in five hours.
3) Inprogesterone pretreated animals, arterial pressure
rises 15% during a five hour saline infusion.
4) In salt fed animals, aldosterone infusion raises the
arterial pressure 30% in five hours.
5) In salt deprived animals, aldosterone infusion raises
the arterial pressure 10\ in five hours.
6) Interference with the ability of both carotid baroreceptors
to detect elevated pressure bymeans of
encapsulation results in a 38% chronic hyPertension
maintained for at least 50days.
7) Infusions of noradrenaline are far less effective in
raising the arterial pressure in decerebrate animals
with lively baroreceptor reflexes than in decerebrate
anaesthetised animals whose baroreceptor reflexes have
been muted by the anaesthetic.
8) Aldosterone selectively perfused through the carotid sinus
can raise arterial pressure. Aldosterone infused into
animals whose carotid baroreceptors are externally perfused,
and protected from exposure to the aldosterone, has no
effect upon arterial pressure. Aldosterone infusion
has no significant effect upon the arterial pressure of
a nembutal anaesthetised animal.
9) Infusion of 0.3 mg/kg/hr of cholesterol emulsion in saline
raises the arterial pressure 45% in four hours. Infusion
of plasma bound cholesterol in the same amounts raises
the arterial pressure 15\ in four hours. Infusion of
emulsified talc in the same amount has no effect on
10) Administration of a diet high in unsaturated fats to
rabbits results in an elevation of arterial pressure
beginning 6 days after starting the experimental diet, and
reaching a peak of 40 above control after 24 days.
During the course of the experiment, there was no change
in the plasma cholesterol concentration.||en
|dc.subject||Steroids arterial pressure||en
|dc.title||Steroids arterial pressure and the baroreceptors||en
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya||
|local.publisher||School of Medicine||en