Cell-free human immunodeficiency virus type 1 in breast milk

Date
1998Author
Lewis, P
Nduati, RW
Kreiss, JK
John, GC
Richardson, BA
Mbori-Ngacha, DA
Ndinya-Achola, JO
Overbaugh, J
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Breast-feeding may be an important route of human immunodeficiency virus type 1 (HIV-1) vertical transmission in settings where it is routinely practiced. To define the prevalence and quantity of HIV-1 in cell-free breast milk, samples from HIV-1-seropositive women were analyzed by quantitative competitive reverse transcription-polymerase chain reaction (QC-RT-PCR). HIV-1 RNA was detected in 29 (39%) of 75 specimens tested. Of these 29 specimens, 16 (55%) had levels that were near the detection limit of the assay (240 copies/mL), while 6 (21%) had >900 copies/mL. The maximum concentration of HIV-1 RNA detected was 8100 copies/mL. The prevalence of cell-free HIV-1 was higher in mature milk (47%) than in colostrum (27%
URI
http://www.ncbi.nlm.nih.gov/pubmed/9419167http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/28344
Citation
J Infect Dis. 1998 Jan;177(1):34-9Publisher
University of Nairobi Faculty of medicine
Collections
- Faculty of Health Sciences (FHS) [10227]