Use of nonoxynol-9 and changes in vaginal lactobacilli
dc.contributor.author | Richardson, BA | |
dc.contributor.author | Martin, HL Jr | |
dc.contributor.author | Stevens, CE | |
dc.contributor.author | Hillier, SL | |
dc.contributor.author | Mwatha, AK | |
dc.contributor.author | Chohan, BH | |
dc.contributor.author | Nyange, PM | |
dc.contributor.author | Mandaliya, K | |
dc.contributor.author | Ndinya-Achola, JO | |
dc.contributor.author | Kreiss, JK | |
dc.date.accessioned | 2013-05-31T12:42:08Z | |
dc.date.available | 2013-05-31T12:42:08Z | |
dc.date.issued | 1998-08 | |
dc.identifier.citation | J Infect Dis. 1998 Aug;178(2):441-5 | en |
dc.identifier.uri | http://profiles.uonbi.ac.ke/jndinya/publications/richardson-ba-martin-hl-jr-stevens-ce-hillier-sl-mwatha-ak-chohan-bh-nyange-pm | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/28387 | |
dc.description.abstract | Several in vitro studies have shown nonoxynol-9 (N-9) to be toxic to lactobacilli, especially to strains that produce H2O2. Data from a randomized, double-blind, placebo-controlled crossover trial that investigated the safety and toxicity of 2 weeks of daily vaginal application of an N-9 gel were analyzed, to examine the effect of N-9 use on vaginal lactobacilli and bacterial vaginosis. In vivo, N-9 promoted sustained colonization by H2O2-producing lactobacilli among women already colonized (relative risk [RR], 1.8; 95% confidence interval [CI], 1.2-2.7). In addition, use of N-9 for 2 weeks reduced the likelihood of bacterial vaginosis (RR, 0.5; 95% CI, 0.3-1.0). In contrast, N-9 use by women initially colonized only by non-H2O2-producing lactobacilli resulted in loss of vaginal lactobacilli (RR, 2.5; 95% CI, 1.2-5.3). These data suggest that daily use of N-9 does not adversely affect vaginal colonization by H2O2-producing lactobacilli but that such use may promote loss of non-H2O2-producing strains. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Use of nonoxynol-9 and changes in vaginal lactobacilli | en |
dc.type | Article | en |
local.publisher | Faculty of medicine | en |
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