Evaluation Of The Size Of Manotoux Test After BCG Vaccination On Infants And Children Attending The Paediatric Demonstration Unit At Kenyatta National Hospital, Nairobi, And The Maternal And Child Health Clinic At The Coast General Hospital, Mombasa
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Date
1982Author
Mbala-Ntsama, Lazare Martin
Type
ThesisLanguage
enMetadata
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This study has evaluated the Mantoux test in children who
were successfully vaccinated with BCG at birth as indicated by the
presence of a scar (1). Groups of children were evaluated at progressive
intervals 3, 6, 8, 12, 24, 36 and ·18months after
immunisation. 'The.purpose of the study was firstly to determine
what size of positive reaction after Mantoux testing could be
attributed solely to the immunisation and what size should be
considered indicative of active infection and secondly to determine
the appropriate age for booster BCG imrnunlsation, taking into
account the waning of the Mantoux reaction with tirne,
This study, using 1TU (one tuberculin unit) of PPD (purified
protein derivative) has shown that 4 mm and 51l1m reactions were
most characteristic of BCG allergy in the children studied and that
reactions beyond 10 mm were extremely rare. This would suggest
that Mantoux reactions more than 10 mm in size in children below
the age of 4 years should be considered as highly suspicious of
tuberculous infection.
There was a significant reversion of the Mantoux test
reaction to negative (66%)by one year of age, there being a greater
number of negative than positive results, suggestions that booster
BCG should be given at this age in areas of high prevalence of
tuberculosis such as Kenya.
Citation
Masters of Medicine (Paediatrics and Child Health)Publisher
University of Nairobi