Granulocyte function in stable CRF and end-stage renal disease patients on haemodialysis at Kenyatta National Hospital
Abstract
Phagocytosis and the ability to kill Candida albicans in-vitro (candidacidal
activity) In three groups of subjects were compared: Group 1 - patients with
end-stage renal disease (ESRD) on maintenance haemodialysis (H.D) Group 2 -
patients with stable chronic renal failure (CRF) who were not on dialysis. Group
3 - normal healthy controls.
Group 1 were 20; 13 males and 7 females, group 2 were also 20; 14 males
and 6 females and group 3 were 21; 14 males and 7 females.
The study showed that the phagocyt.i.c activity in autologous plasma was
lower in group 2 ( uraemic patients who were not on haemodialysis) than group
1 ( patients who were on haemodialysis) (P<0.02). The phagocytic activity was
also lower in group 2 patients than group 3 ( controls) (P<0.02). When the
neutrophils from group 1, 2 and 3 subjects were suspended in AB rhesus
negative (AB Rh -ve) plasma, the phagocytic activity was lower in group 2 than
group 1 patients (P<0.002). The phagocytic activity in AB Rh -ve plasma for
group 2 patients was also lower than for group 3 (controls) (P<0.002). There was
no significant difference tn neutrophils from group 2 and 3 subjects both in
autologous and AB Rh -ve plasma.
The candidacidal activity of group 3 was the highest of the three groups
but the difference was statistically significant only when comparing groups 2 and
3 (P<0.02). Immunoglobulin and complement profiles in the three groups were
also compared and no significant differences were found.
Citation
Ntarindwa, J(1991).Granulocyte function in stable CRF and end-stage renal disease patients on haemodialysis at Kenyatta National HospitalPublisher
College of Health Sciences, University of Nairobi
Subject
Granulocyte functionCRF and end-stage renal disease
Haemodialysis
Patients
Kenyatta National Hospital
Description
Master of Medicine Thesis