beta S-haplotypes and alpha-thalassemia along the coastal belt of Kenya.
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Date
1989-06Author
Ojwang, PJ
Ogada, T
Gonzalez-Redondo, JM
Kutlar, A
Kutlar, F
Huisman, TH
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
In this paper, we present data on studies of beta S-haplotypes and alpha-thalassemia gene in subjects from the indigenous population of the Coast Province of Kenya Of the 7SS patients studied, four were homozygous for beta S-haplotype 20 characteristically associated with the severe form of sickle cell anemia found in the Central African Republic and Western Kenya. Two had haplotype 20 combined with haplotype 19 (Benin Type) and one had haplotype 20 combined with a new haplotype (20x). Alpha thalassaemia-2 gene (-3.7kb deletion) was detected in 45.6% of the 57AA subjects studied. An alpha globin gene triplication was detected in one subject whereas eight had gamma globin gene triplication.
URI
http://www.ncbi.nlm.nih.gov/pubmed/2791941http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/29361
Citation
East Afr Med J. 1989 Jun;66(6):377-80Publisher
University of Nairobi School of medicine
Collections
- Faculty of Health Sciences (FHS) [10378]