T-lymphocyte subsets in idiopathic dilated cardiomyopathy.

dc.contributor.author	Sanderson, JE
dc.contributor.author	Koech, D
dc.contributor.author	Iha, D
dc.contributor.author	Ojiambo, Hilary P
dc.date.accessioned	2013-06-06T13:53:11Z
dc.date.available	2013-06-06T13:53:11Z
dc.date.issued	1985
dc.identifier.citation	Am J Cardiol. 1985 Mar 1;55(6):755-8.	en
dc.identifier.uri	http://www.ncbi.nlm.nih.gov/pubmed/3156482
dc.identifier.uri	http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/29391
dc.description.abstract	Idiopathic dilated cardiomyopathy (IDC) is a common clinical problem in Africa. To determine if there is a defect of immune regulation in patients with IDC, the percentage of total T-cells (OKT3 positive), helper/inducer cells (OKT4 positive) and suppressor/cytotoxic cells (OKT8 positive) were measured using monoclonal antibodies in 20 patients with IDC and in 20 age-matched normal control subjects. The percentage of helper/inducer cells was significantly higher in the IDC patients (45 +/- 2% mean +/- standard error) than in the normal subjects (33 +/- 2%) and 8 of the 20 IDC patients had a helper/suppressor cell ratio (OKT4/OKT8) higher than the normal range. Of the 8 patients with this abnormality, 7 were studied within 3 months of the onset of their illness. Results suggest that an excessive immune reaction is part of the pathogenesis of IDC in Africans.	en
dc.language.iso	en	en
dc.title	T-lymphocyte subsets in idiopathic dilated cardiomyopathy.	en
dc.type	Article	en
local.publisher	College of health science,University of Nairobi	en