dc.contributor.author | Gichangi, P | |
dc.contributor.author | Bwayo, JJ | |
dc.contributor.author | Estambale Benson B. | |
dc.contributor.author | Rogo Khama O. | |
dc.contributor.author | Njuguna, E | |
dc.contributor.author | Ojwang, S | |
dc.contributor.author | Temmerman, M | |
dc.date.accessioned | 2013-06-06T15:10:54Z | |
dc.date.available | 2013-06-06T15:10:54Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | Gynecol Oncol. 2006 Feb;100(2):405-11 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/16274737 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/29531 | |
dc.description.abstract | To determine the impact of HIV infection on acute morbidity and pelvic tumor control following external beam radiotherapy (EBRT) for cervical cancer.
METHOD:
218 patients receiving EBRT who also had HIV testing after informed consent was obtained were evaluated. Acute treatment toxicity was documented weekly during treatment and 1 month post-EBRT. Pelvic tumor control was documented at 4 and 7 months post-EBRT. Clinicians were blinded for HIV results.
RESULTS:
About 20% of the patients were HIV-positive. Overall, 53.4% of the patients had radiation-related acute toxicity (grade 3-4). HIV infection was associated with a 7-fold higher risk of multisystem toxicity: skin, gastrointestinal tract (GIT) and genitourinary tract (GUT) systems. It was also an independent risk factor for treatment interruptions (adjusted relative risk 2.2). About 19% of the patients had residual tumor at 4 and 7 months post-EBRT. HIV infection was independently and significantly associated with 6-fold higher risk of residual tumor post-EBRT. The hazard ratio of having residual tumor after initial EBRT was 3.1-times larger for HIV-positive than for HIV-negative patients (P = 0.014).
CONCLUSION:
HIV is associated with increased risk of multisystem radiation-related toxicity; treatment interruptions and pelvic failure (residual tumor) following EBRT. HIV infection is an adverse prognostic factor for outcome of cervical cancer treatment | en |
dc.language.iso | en | en |
dc.title | HIV impact on acute morbidity and pelvic tumor control following radiotherapy for cervical cancer | en |
dc.type | Article | en |
local.publisher | Department of Human Anatomy, University of Nairobi, | en |
local.publisher | Department of Obstetrics and Gynaecology, | en |