Prolactin and hypertension
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Date
1977Author
Mati, J K
Mugambi, M
Odipo, W S
Nguli, K
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Progesterone (2.5 mg per kilogram) caused sustained hypertension in rabbits. When the same dose of progesterone was administered together with prolactin (1.25 mg. per kilogram), there was no increase in the blood pressure. In rabbits with progesterone-induced hypertension, the addition of prolactin caused a sharp drop in blood pressure. It is suggested that prolactin acts by reducing the sensitivity of the blood vessels to circulating pressor substances and further that a reduced prolactin response may be the cause of heightened sensitivity to pressor substances observed in pre-eclampsia.
URI
http://www.ncbi.nlm.nih.gov/pubmed/842588http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/29572
Citation
Am J Obstet Gynecol. 1977 Mar 15;127(6):616-9.Collections
- Faculty of Health Sciences (FHS) [10378]