Effect of prolactin on isolated rabbit myometrium
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Date
1974Author
Mati, J. K
Mugambi, M
Muriuki, P. B
Thairu, K
Type
ArticleLanguage
enMetadata
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Reports in recent years that normal levels of human chorionic somato-mammotrophin (HCS) in cases of threatened abortion are associated with continuation of pregnancy (Genazzani, Aubert, Casoli, Fioretti & Felber, 1969; Singer, Desjardins & Friesen, 1970; Niven, Landon & Chard, 1972) have led to the suggestion that lactogenic hormones may play a role in the maintenance of pregnancy. Sheep prolactin at a concentration of 10 μg/ml has been shown to exert a marked inhibitory effect on myometrial activity in pregnant guinea-pigs (Manku & Horrobin, 1973), rats primed with oestrogen and progesterone (Horrobin, Lipton, Muiruri, Manku, Bramley & Burstyn, 1973), as well as in non-pregnant human myometrium (Mugambi, Mati, Thairu & Muriuki, 1973). In the present study we show that sheep pituitary prolactin at a dose of 40 μg/ml exerts a less inhibitory effect on pregnant rabbit myometrium than in the species quoted above.
URI
http://www.ncbi.nlm.nih.gov/pubmed/4815994http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/29703
http://joe.endocrinology-journals.org/content/60/2/379.extract
Citation
J Endocrinol. 1974 Feb;60(2):379-80Collections
- Faculty of Health Sciences (FHS) [10387]