Human leukocyte antigen class II DQ alleles associated with Chlamydia trachomatis tubal infertility.
Date
2000Author
Cohen, CR
Sinei, S
Bukusi, EA
Bwayo, JJ
Holmes, KK
Brunham, RC
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
OBJECTIVE:
To investigate epidemiologic tubal infertility risk factors and the relationship between HLA class II alleles and Chlamydia trachomatis tubal infertility.
METHODS:
Forty-seven women with tubal infertility and 46 fertile controls were studied in Nairobi, Kenya. A questionnaire was administered and serum collected for measurement of C trachomatis antibodies. HLA class II molecular typing was done with DNA extracted from peripheral blood lymphocytes. The prevalence of C trachomatis microimmunofluorescence antibody, chlamydia heat shock protein 60 antibody, and HLA class II alleles was compared among cases of tubal infertility and fertile controls.
RESULTS:
Women with tubal infertility more often had histories of pelvic inflammatory disease (15% versus 0%; odds ratio [OR] 16; 95% confidence interval [CI] 5.5, 47) histories of spontaneous abortion (34% versus 7%; OR 6.7; 95% CI 2.8, 16), and antibodies to C trachomatis (53% versus 26%; OR 3.2; 95% CI 1.3, 7.7) than controls. Among infertile women, DQA*0101 and DQB*0501 alleles were positively associated with C trachomatis tubal infertility (OR 4.9; 95% CI 1.3, 18.6, and OR 6.8; 95% CI 1.6, 29.2, respectively). DQA*0102 was negatively associated with C trachomatis tubal infertility (OR 0.2; 95% CI 0.005, 0.6).
CONCLUSION:
Chlamydia trachomatis infection is an important cause of tubal infertility in Nairobi. The association of specific HLA class II alleles with C trachomatis microimmunofluorescence seropositivity among women with tubal infertility suggests that the DQ locus might modify susceptibility to and pathogenicity of C trachomatis infection.
URI
http://www.ncbi.nlm.nih.gov/pubmed/10636506http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/29994
Citation
Obstet Gynecol. 2000 Jan;95(1):72-7.Publisher
Department of Obstetrics and Gynecology, University of Washington, Seattle 98104-6460, USA. crcohen@u.washington.edu
Collections
- Faculty of Health Sciences (FHS) [10377]