Effects Of Chronic Administration Of Mianserin And Clomipramine Of Tryptophan Hydroxylase Activity In The Rat Brain
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Date
1986Author
Redfern, p H
Sinei, KA
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The activity of tryptophan hydroxylase was measured in the rat brainstem and cortex by the rate of in vivo accumulation of 5-hydroxytryptophan after inhibition of aromatic amino acid decarboxylase with 3-hydroxybenzyl-hydrazine. The activity of the enzyme was higher at mid-dark than mid-light in the two brain areas. Chronic administration of clomipramine increased the enzymatic activity at the two times of day to different levels of significance. In contrast, chronic mianserin led to a decrease but only to different levels of significance in the cortex. The significance of these results are discussed in relation to the theories implicating circadian rhythms in the mechanism of antidepressant action.
URI
Http://profiles.uonbi.ac.ke/kipruto_sinei/publications/effects-chronic-administration-mianserin-and-clomipramine-tryptophan-hydrhttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30339
http://www.ncbi.nlm.nih.gov/pubmed/8033776
Citation
Effects Of Chronic Administration Of Mianserin And Clomipramine Of Tryptophan Hydroxylase Activity In The Rat Brain, Redfern, Ph, And Sinei Ka , Br, J. Pharmacol., Volume 88, P.342p, (1986)Publisher
University of Nairobi Department of Pharmacology and Pharmacognosy
Collections
- Faculty of Health Sciences (FHS) [10377]