Effect of temperature and cardiopulmonary bypass on the pharmacokinetics of remifentanil
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Date
1997Author
Russell, D
Royston, D
Rees, P. H
Gupta, S. K
Kenny, G. N
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Sixteen patients undergoing coronary revascularization requiring cardiopulmonary bypass received remifentanil 2 micrograms kg-1 or 5 micrograms kg-1 by infusion over 1 min after sternotomy but before commencing cardiopulmonary bypass, during hypothermic cardiopulmonary bypass and during cardiopulmonary bypass after rewarming. Hypothermic cardiopulmonary bypass reduced the clearance of remifentanil by an average of 20%, and this was attributed to the effect of temperature on blood and tissue esterase activity. Reductions in arterial pressure occurred with administration of both doses during normothermia only.
URI
http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/9389262http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30342
Citation
Br J Anaesth. 1997 Oct;79(4):456-9.Collections
- Faculty of Health Sciences (FHS) [10377]