dc.contributor.author | Olowookere, J O | |
dc.contributor.author | Konji, V N | |
dc.contributor.author | Makawiti, D W | |
dc.contributor.author | Kiaira, J K | |
dc.contributor.author | Kamau, J M | |
dc.contributor.author | Omwandho, C A | |
dc.date.accessioned | 2013-06-10T08:33:31Z | |
dc.date.available | 2013-06-10T08:33:31Z | |
dc.date.issued | 1991 | |
dc.identifier.citation | Defects in resting metabolic rates and mitochondrial respiration in Kwashiorkor and dietary obese rats. Olowookere JO, Konji VN, Makawiti DW, Kiaira JK, Kamau JM, Omwandho CA. J Comp Physiol B. 1991;161(3):319-22. | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/1939742 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30493 | |
dc.description.abstract | Resting metabolic rates have been measured and compared with hepatic mitochondrial respiration in Kwashiorkor and diet-induced obese weaned rats. In Kwashiorkor, resting metabolic rate was 21% lower than the value of controls, while that of the obese rats was 14% higher than in control animals. The resting metabolic rate for Kwashiorkor animals was 50% of the predicted basal metabolic rate (BMR), whereas that of the obese rats was 23% higher than the predicted BMR. The mitochondrial oxygen consumption patterns, using malate plus glutamate or succinate as respiratory substrates, revealed that the resting respiration (state 4) was 23.9% higher in Kwashiorkor and 29.1% higher in obese animals, while the active (state 3) respiration was 34.8% lower in Kwashiorkor and 43.3% lower in obese rats compared to controls. The respiratory control ratios (RCR) were 51.1% and 43.8% in Kwashiorkor and obese rats, respectively, relative to the values in control rats. It is concluded from these studies that Kwashiorkor disease and diet-induced obesity appear to interfere with oxygen utilization at the level of state 3 mitochondrial respiration, which is markedly decreased when compared to the values for control animals. | en |
dc.language.iso | en | en |
dc.title | Defects in resting metabolic rates and mitochondrial respiration in Kwashiorkor and dietary obese rats. | en |
dc.type | Article | en |
local.publisher | Biomembranes and Bioenergetics Research Laboratory, Ogun State University, Ago-Iwoye, Nigeria. | en |