dc.contributor.author | Fowler, M J | |
dc.contributor.author | Greenfield, C | |
dc.contributor.author | Duarayiannis, K | |
dc.contributor.author | Chu, C | |
dc.contributor.author | Karayiannis, P | |
dc.contributor.author | Dunk, A | |
dc.contributor.author | Lok, A S | |
dc.contributor.author | Lai, C L | |
dc.contributor.author | Yeoh, E K | |
dc.contributor.author | Monjardino, J P, | |
dc.contributor.author | Wankya, B M | |
dc.contributor.author | et al. | |
dc.date.accessioned | 2013-06-10T09:02:55Z | |
dc.date.available | 2013-06-10T09:02:55Z | |
dc.date.issued | 1986 | |
dc.identifier.citation | J Hepatol. 1986;2(2):218-29 | en |
dc.identifier.uri | http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/3958473 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30543 | |
dc.description.abstract | Hundred and ten liver biopsy specimens from various parts of the world were examined for episomal and integrated HBV-DNA sequences. In 54 patients with HBsAg chronic liver disease episomal HBV-DNA was found in 83% of HBeAg-positive patients, compared to only 22% of patients with anti-HBe. Furthermore episomal HBV-DNA in the latter predominated among the Asians. Integrated HBV-DNA was found only in 5.5% of HBeAg-positive patients but in 16.5% of patients with anti-HBe. In 28 HBsAg-positive patients with hepatoma, episomal HBV-DNA was found in 50% of HBeAg-positive patients but in only 11% of anti-HBe patients. Conversely integrated sequences were less common (25%) in HBe-Ag-positive patients than in anti-HBe patients (50%), giving an overall incidence of integration in this group of 45%. No episomal, and only one case of integrated sequences of HBV-DNA, could be detected among 10 patients with HBsAg-negative hepatoma. In addition neither episomal nor integrated HBV-DNA could be detected in 18 patients with non-HBV-related liver disease. Our data suggests that stable integration of HBV-DNA into the host's genome is not necessarily a prerequisite for the maintenance of the state of malignant transformation but may be necessary for its initiation. Alternatively, the detection of integrated HBV-DNA may represent a 'snap shot' of a random integration event amplified by clonal expansion promoted by other factors | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Integration of HBV-DNA may not be a prerequisite for the maintenance of the state of malignant transformation. An analysis of 110 liver biopsies | en |
dc.type | Article | en |
local.publisher | School of medicine | en |