The root of many evils: indolent large granular lymphocyte leukaemia and associated disorders
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Date
2010Author
Zhang, R
Shah, MV
Loughran, TP Jr.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Large granular lymphocytes (LGL) leukaemia can arise from either natural killer (NK) cells or cytotoxic T lymphocytes (CTL). The T-cell form of LGL leukaemia has significant overlap with other haematological disorders and autoimmune diseases. Here we provide an overview of LGL biology. We also focus discussion on the indolent LGL leukaemia related disorders and their causal relationships. We then discuss the potential relationships and distinctions between indolent LGL leukaemia and non-malignant clonal lymphocyte expansion that occur in otherwise healthy individuals, especially elder people.
URI
www.ncbi.nlm.nih.gov/whalecom0/pubmed/19645074http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30580
Citation
Hematol Oncol. 2010 Sep;28(3):105-17. doi: 10.1002/hon.917.Publisher
Penn State Hershey Cancer Institute, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Collections
- Faculty of Health Sciences (FHS) [10378]