dc.contributor.author | Gichuhi, C | |
dc.contributor.author | Obimbo, E | |
dc.contributor.author | Mbori-Ngacha, DA | |
dc.contributor.author | Mwatha, A | |
dc.contributor.author | Otieno, P | |
dc.contributor.author | Farquhar, C | |
dc.contributor.author | Wariua, G | |
dc.contributor.author | Wamalwa, D | |
dc.contributor.author | Bosire, R | |
dc.contributor.author | John-Stewart, G | |
dc.date.accessioned | 2013-06-10T10:02:07Z | |
dc.date.available | 2013-06-10T10:02:07Z | |
dc.date.issued | 2005-09 | |
dc.identifier.citation | East Afr Med J. 2005 Sep;82(9):447-51. | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/16619717 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30636 | |
dc.description.abstract | OBJECTIVES:
To identify potential predictors of mortality, to determine mortality rate and to identify prevalent causes of death in a cohort of HIV-1 exposed uninfected infants.
DESIGN:
Prospective cohort study.
SETTING:
Kenyatta National Hospital, Nairobi, Kenya.
SUBJECTS:
Three hundred and fifty one HIV-1 exposed uninfected post-neonatal infants who survived to one year of age.
RESULTS:
Sixteen infants died (post-neonatal mortality rate of 47/1000 live births), 14 (88%) before six months of age. The most frequently identified medical conditions at death included bronchopneumonia, diarrhoea and failure to thrive. In multivariate analysis, prematurity (RR=10.5, 95%CI 3.8-29.1, p<0.001), teenage motherhood (RR=3.6, Cl 1.0-13.2, p=0.05) and symptomatic maternal HIV-1 disease (RR=2.7, CI 0.9-7.7, p=0.06) were associated with infant mortality.
CONCLUSION:
Prematurity, teenage motherhood and symptomatic HIV-1 maternal disease were important predictors for post-neonatal mortality in this cohort of HIV-1 exposed uninfected infants. These factors should be considered in monitoring and follow up in prevention of mother-to-child HIV-1 transmission (PMTCT) programs. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi. | en |
dc.title | Predictors of mortality in HIV-1 exposed uninfected post-neonatal infants at the Kenyatta National Hospital, Nairobi. | en |
dc.type | Article | en |
local.publisher | Department of Clinical Pharmacology and Therapeutics, College of Health Sciences, University of Nairobi | en |
local.publisher | Department of Paediatrics and Child Health, Univeristy of Nairobi, Kenya | en |