dc.contributor.author | Choi, RY | |
dc.contributor.author | Farquhar, C | |
dc.contributor.author | Juno, J | |
dc.contributor.author | Mbori-Ngacha, DA | |
dc.contributor.author | Lohman-Payne, B | |
dc.contributor.author | Vouriot, F | |
dc.contributor.author | Wayne, S | |
dc.contributor.author | Tuff, J | |
dc.contributor.author | Bosire, R | |
dc.contributor.author | John-Stewart, G | |
dc.contributor.author | Fowke, K | |
dc.date.accessioned | 2013-06-10T12:29:18Z | |
dc.date.available | 2013-06-10T12:29:18Z | |
dc.date.issued | 2010-06 | |
dc.identifier.citation | Clin Exp Immunol. 2010 Jun;160(3):461-5 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/20132229 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30804 | |
dc.description.abstract | The C868T single nucleotide polymorphism (SNP) in the CD4 receptor encodes an amino acid change that could alter its structure and influence human immunodeficiency virus (HIV-1) infection risk. HIV-1-infected pregnant women in Nairobi were followed with their infants for 1 year postpartum. Among 131 infants, those with the 868T allele were more likely than wild-type infants to acquire HIV-1 overall [hazard ratio (HR) = 1.92, 95% confidence interval (CI) 1.05, 3.50, P = 0.03; adjusted HR = 2.03, 95% CI 1.03, 3.98, P = 0.04], after adjusting for maternal viral load. This SNP (an allele frequency of approximately 15% in our cohort) was associated with increased susceptibility to mother-to-child HIV-1 transmission, consistent with a previous study on this polymorphism among Nairobi sex workers. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi. | en |
dc.title | Infant CD4 C868T polymorphism is associated with increased human immunodeficiency virus (HIV-1) acquisition | en |
dc.type | Article | en |
local.publisher | Department of Paediatrics and Child Health, Univeristy of Nairobi, Kenya | en |