Tetracycline resistance genes in Kenyan hospital isolates of Salmonella typhimurium.
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Date
1992Author
Kariuki, S
Mirza, NB
Wasteson, Y
Senerwa, D
Gathuma, JM
Olsvik, O.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
All 97 strains of Salmonella typhimurium isolated from patients at a hospital in Nairobi, Kenya, during 1988-90 were resistant to tetracycline. The minimum inhibitory concentration (MIC) showed a large distribution range from 1 microgram/ml to 128 micrograms/ml. The strains were heterogeneous with respect to plasmid content, but initially all strains possessed, in addition to other plasmids, a large 60-, 63- or 65-MDa plasmid. The tetracycline resistance genes were characterized using oligonucleotide probes, and 20% of the resistant strains possessed tetracycline type A (tetr A), 6% tetr B, and 4% tetrC genes. Three strains possessed both type A and B tetracycline resistance determinants, which were shown to be located on the large 65-MDa plasmid. There was no correlation between strains isolated from stools, blood, cerebrospinal or epidural fluids, pus, or urine, with respect to the tetracycline genotypes, MIC values or plasmid content.
PMID:
1642850
[PubMed - indexed for MEDLINE]
URI
http://www.ncbi.nlm.nih.gov/pubmed/1642850http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30886
Citation
Tetracycline resistance genes in Kenyan hospital isolates of Salmonella typhimurium. Kariuki S, Mirza NB, Wasteson Y, Senerwa D, Gathuma JM, Olsvik O. APMIS. 1992 Jul;100(7):629-34.Publisher
Medicine, University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10387]