In vitro activities of 2,4-diaminoquinazoline and 2,4-diaminopteridine derivatives against Plasmodium falciparum

dc.contributor.author	Ommeh, S
dc.contributor.author	Nduati, E
dc.contributor.author	Mberu, E
dc.contributor.author	Kokwaro, G
dc.contributor.author	Marsh, K
dc.contributor.author	Rosowsky, A
dc.contributor.author	Nzila, A
dc.date.accessioned	2013-06-10T15:04:38Z
dc.date.available	2013-06-10T15:04:38Z
dc.date.issued	2004
dc.identifier.citation	Antimicrob Agents Chemother. 2004 Oct;48(10):3711-4	en
dc.identifier.uri	http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/31034
dc.identifier.uri	http://www.ncbi.nlm.nih.gov/pubmed/15388424
dc.description.abstract	The activities of 28 6-substituted 2,4-diaminoquinazolines, 2,4-diamino-5,6,7,8-tetrahydroquinazolines, and 2,4-diaminopteridines against Plasmodium falciparum were tested. The 50% inhibitory concentrations (IC(50)s) of six compounds were <50 nM, and the most potent compound was 2,4-diamino-5-chloro-6-[N-(2,5-dimethoxybenzyl)amino]quinazoline (compound 1), with an IC(50) of 9 nM. The activity of compound 1 was potentiated by the dihydropteroate synthase inhibitor dapsone, an indication that these compounds are inhibitors of dihydrofolate reductase. Further studies are warranted to assess the therapeutic potential of this combination in vivo	en
dc.description.uri
dc.language.iso	en	en
dc.publisher	University of Nairobi	en
dc.title	In vitro activities of 2,4-diaminoquinazoline and 2,4-diaminopteridine derivatives against Plasmodium falciparum	en
dc.type	Article	en
local.publisher	School of Medicine	en