dc.contributor.author | Amin, AA | |
dc.contributor.author | Hughes, DA | |
dc.contributor.author | Marsh, V | |
dc.contributor.author | Abuya, TO | |
dc.contributor.author | Kokwaro, G | |
dc.contributor.author | Winstanley, PA | |
dc.contributor.author | Ochola, SA | |
dc.contributor.author | Snow, RW | |
dc.date.accessioned | 2013-06-10T15:16:33Z | |
dc.date.available | 2013-06-10T15:16:33Z | |
dc.date.issued | 2004 | |
dc.identifier.citation | Trop Med Int Health. 2004 Sep;9(9):967-74 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/15361109 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/31044 | |
dc.description.abstract | Objective:To demonstrate the difference between effectiveness and efficacy of antimalarial (AM) drugs in Kenya.
Methods:We undertook a series of linked surveys in four districts of Kenya between 2001 and 2002 on (i) community usage of nationally recommended first- and second-line AM drugs; (ii) commonly stocked AM products in the retail and wholesale sectors; and (iii) quality of the most commonly available first- and second-line AM products. These were combined with estimates of adherence and clinical efficacy to derive overall drug effectiveness. Results: The overall modelled effectiveness for sulphadoxine-pyrimethamine (SP) was estimated to be 62% compared with 85% for reported SP clinical efficacy. For amodiaquine the modelled effectiveness was 48% compared with 99% reported efficacy during the same time period. Conclusion: The quality of AM products and patient adherence to dosage regimens are important determinants of drug effectiveness, and should be measured alongside clinical efficacy. Post-registration measures to regulate drug quality and improve patient adherence would contribute significantly to AM drug performance | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | The difference between effectiveness and efficacy of antimalarial drugs in Kenya | en |
dc.type | Article | en |
local.publisher | College of Humanities Sciences | en |