dc.contributor.author | Biggar, RJ | |
dc.contributor.author | Johnson, BK | |
dc.contributor.author | Oster, C | |
dc.contributor.author | Sarin, PS | |
dc.contributor.author | Ocheng, D | |
dc.contributor.author | Tukei, P | |
dc.contributor.author | Nsanze, H | |
dc.contributor.author | Alexander, S | |
dc.contributor.author | Bodner, AJ | |
dc.contributor.author | Siongok, TA | |
dc.date.accessioned | 2013-06-11T08:00:33Z | |
dc.date.available | 2013-06-11T08:00:33Z | |
dc.date.issued | 1985-06 | |
dc.identifier.citation | Int J Cancer. 1985 Jun 15;35(6):763-7. | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/2989191 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/31195 | |
dc.description.abstract | The prevalence of antibodies against HTLV-III and -I was studied among populations of 6 distinctly different regions of Kenya, an equatorial African country in which AIDS has rarely been observed. Overall, 21% of subjects had ELISA reactions suggesting the presence of antibody against HTLV-III. The frequency of HTLV-III antibodies was highest among the Turkana people (50%) and lowest among the Masai (8%). Prevalence increased with age but was not related to sex. The pattern of ELISA-detected antibody against HTLV-I was similar. The specificity of these antibodies was supported by Western blot analysis of a subset of sera with high and low ELISA ratios, in which 66% and 73% of those with ELISA ratios considered positive (= greater than 5.0 in this study) also had a profile of bands consistent with HTLV-III and HTLV-I respectively. The antibodies detected were not cross-reactive between HTLV-III and HTLV-I on Western blot analysis. In a series of subjects with various parasitic and infectious diseases, patients with idiopathic splenomegaly and with schistosomiasis had a high proportion of antibodies against both HTLV-III and HTLV-I. This survey shows that reactivity in the ELISA HTLV-III and HTLV-I assays are common among Kenyans but vary considerably by region | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi, | en |
dc.title | Regional variation in prevalence of antibody against human T-lymphotropic virus types I and III in Kenya, East Africa | en |
dc.type | Article | en |
local.publisher | Department of Medicine | en |