Ki-67 antigen in ameloblastomas: correlation with clinical and histological parameters in 54 cases from Kenya
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Date
1997Author
Ong'uti, MN
Cruchley, AT
Howells, GL
Williams, DM
Type
ArticleLanguage
enMetadata
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The aim of this study was to assess the cell proliferation in ameloblastomas and to correlate this with clinical features and histology. Immunohistochemistry with Ki-67 monoclonal antibody was performed on fresh tissue from 54 ameloblastomas. A labelling index (LI) was calculated by expressing the percentage of Ki-67 positive cells. There was no significant correlation between LI and clinical features: age, sex or tumour size. Follicular ameloblastomas had significantly higher LI (5.0 +/- 0.5; mean +/- SEM) than plexiform tumours (3.2 +/- 0.6; P < 0.05). Plexiform ameloblastomas from the anterior mandible had a significantly lower LI (1.8 +/- 0.5) than those from the posterior (3.9 +/- 0.8; P < 0.05). LI was higher in squamous arcades (6.4 +/- 3.1%) than in epithelial cords and cysts (1.4 +/- 1.3%; P < 0.001). These results suggest that LI correlates most closely with the histological pattern of the epithelium of ameloblastoma, both within and between different tumours.
URI
http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/9327291http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/31785
Citation
Int J Oral Maxillofac Surg. 1997 Oct;26(5):376-9Publisher
College of Health Sciences, University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10378]