dc.contributor.author | Estambale Benson B. | |
dc.contributor.author | Howells RE. | |
dc.date.accessioned | 2013-06-12T08:48:42Z | |
dc.date.available | 2013-06-12T08:48:42Z | |
dc.date.issued | 1989-07 | |
dc.identifier.citation | Zentralbl Bakteriol. 1989 Jul;271(2):249-55 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/2775429 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/32064 | |
dc.description.abstract | An in vitro study of the antinematodal action of two groups of compounds which act on the receptor complex of the inhibitory neurotransmitter, Gamma-aminobutyric acid (GABA) in mammalian systems is described. The compounds, Ivermectin and two benzodiazepines, Diazepam and a water soluble Midazolam were tested singly or in combination against two microfilarial parasites Onchocerca lienalis (closely related to Onchocerca volvulus) and Brugia pahangi. The combination of ivermectin and diazepam at a concentration of 0.1 microgram/ml and 33 micrograms/ml respectively achieved the same effect on microfilarial motility as when ivermectin was given at 1 microgram/ml alone or diazepam at 66 micrograms/ml alone. Similarly when the combination of ivermectin at 0.1 microgram/ml and midazolam at 10 micrograms/ml was used it achieved the same effect as ivermectin at 1 microgram/ml alone or midazolam at 33 micrograms/ml alone. This showed that both benzodiazepines had a synergistic effect on the activity of ivermectin. The microfilariae of B. pahangi were insensitive to both groups of compounds at all concentrations used | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi. | en |
dc.title | The efficacy of 22,23-dihydroavermectin B1 (Ivermectin) acting singly or in combination with a benzodiazepine on microfilariae of Onchocerca species and Brugia pahangi (an in vitro study) | en |
dc.type | Article | en |
local.publisher | Department of Medical Microbiology, College of Health Sciences, University of Nairobi, Kenya. | en |