dc.contributor.author | Slyker, JA | |
dc.contributor.author | Casper, C | |
dc.contributor.author | Tapia, K | |
dc.contributor.author | Richardson, B | |
dc.contributor.author | Bunts, L | |
dc.contributor.author | Huang, ML | |
dc.contributor.author | Maleche-Obimbo, E | |
dc.contributor.author | Nduati, RW | |
dc.contributor.author | John-Stewart, G | |
dc.date.accessioned | 2013-06-12T08:55:43Z | |
dc.date.available | 2013-06-12T08:55:43Z | |
dc.date.issued | 2013-06 | |
dc.identifier.citation | J Infect Dis. 2013 Jun;207(12):1798-806. doi: 10.1093/infdis/jit093. Epub 2013 Mar 14 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/23493724 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/32076 | |
dc.description.abstract | Background. Human immunodeficiency virus (HIV) infection is a risk factor for Epstein-Barr virus (EBV)-associated lymphomas. Characterizing primary infection may elucidate risk factors for malignancy. Methods. To describe clinical and virologic manifestations of primary EBV infection among infants born to HIV-infected women, specimens were utilized from a cohort study conducted in Nairobi, Kenya. HIV and EBV viral loads were measured serially in plasma. EBV serology was performed on EBV DNA-negative infants. Monthly clinical examinations were performed by pediatricians. Results. The probability of EBV infection by 1 year of age was .78 (95% CI, .67-.88) in HIV-infected and .49 (95% CI, .35-.65) in HIV-uninfected infants (P < .0001). At 2 years, probability of EBV infection was .96 (95% CI, .89-.99) in HIV-infected infants. Peak EBV loads were higher in HIV-infected versus HIV-uninfected infants (median 2.6 vs 2.1 log10 copies/mL; P < .0001). The majority of HIV-infected infants had detectable EBV DNA for >3 months (79%). Primary EBV infection was associated with cough, fever, otitis media, pneumonia, hepatomegaly, splenomegaly, and hospitalization in HIV-infected infants; conjunctivitis and rhinorrhea in HIV-uninfected infants. Conclusions. EBV infection occurs early in infants born to HIV-infected women. HIV infection was associated with more frequent and higher quantity EBV DNA detection. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.subject | EBV, HIV, herpesviruses, pediatric, primary infection | en |
dc.title | Clinical and Virologic Manifestations of Primary Epstein-Barr Virus (EBV) Infection in Kenyan Infants Born to HIV-Infected Women. | en |
dc.type | Article | en |
local.publisher | Department of Pediatrics and Child Health, School of Medicine, University of Nairobi | en |